Thiol-Reactive Metal Compounds Inhibit NF-kB Activation by Blocking IkB Kinase
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چکیده
منابع مشابه
IkB kinase b (IKKb/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-kB
IKKb/IKBKB (IkB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkB molecules, the inhibitors of NF-kB transcription factors. The kinase activity of IKKb targets two adjacent serine residues of IkB leading to ubiquitination and proteasomal degradation of the inhibitor, followed by release and activation of NF-kB. Many signaling pathways that activate NF-kB...
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